Severe combined immunodeficiency disease, X-linked (Corgi type)
Other Names: XSCID
Inheritance: X-Linked Recessive
Mutation(s): 1 bp insertion (ins C)
Affected Gene(s): IL2RG
Affected Breed(s): Cardigan Welsh Corgi, Pembroke Welsh Corgi
Inheritance: X-Linked Recessive
Mutation(s): 1 bp insertion (ins C)
Affected Gene(s): IL2RG
Affected Breed(s): Cardigan Welsh Corgi, Pembroke Welsh Corgi
Common Symptoms
X-linked severe combined immunodeficiency (group B) is an inherited disease affecting dogs. Affected dogs are unable to produce a protein important for proper immune function, predisposing them to severe recurrent or chronic bacterial, viral and fungal infections. Affected dogs often present with symptoms of disease around 6 to 8 weeks of age including failure to thrive, poor growth, weight loss, lethargy, diarrhea, vomiting and lack of palpable lymph nodes. Affected dogs may also present with active respiratory, skin, eye or ear infections. Affected dogs die within 4 months of age.
References
X-linked severe combined immunodeficiency (group B) is an inherited disease affecting dogs. Affected dogs are unable to produce a protein important for proper immune function, predisposing them to severe recurrent or chronic bacterial, viral and fungal infections. Affected dogs often present with symptoms of disease around 6 to 8 weeks of age including failure to thrive, poor growth, weight loss, lethargy, diarrhea, vomiting and lack of palpable lymph nodes. Affected dogs may also present with active respiratory, skin, eye or ear infections. Affected dogs die within 4 months of age.
References
- Pullen RP, Somberg RL, Felsburg PJ, Henthorn PS. X-linked severe combined immunodeficiency in a family of cardigan Welsh corgis. J Am Anim Hosp Assoc. 1997 Nov-Dec;33(6):494-9. [PubMed: 9358416]
- Somberg RL, Pullen RP, Casal ML, Patterson DF, Felsburg PJ, Henthron PS. A single nucleotide insertion in the canine interleukin-2 receptor gamma chain results in X-linked severe combined immunodeficiency disease. Vet Immunol Immunopathol. 1995 Aug;47(3-4):203-13. [PubMed: 8571541]